KYNU polyclonal Antibody | BS8320

KYNU polyclonal Antibody | BS8320 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Kynureninase, also known as L-kynurenine hydrolase, is a 465 amino acid cytoplasmic enzyme. Kynureninase is involved in two pathways; the degredation of L-kynurenine and the biosynthesis of the cofactor NAD (+) . The main function of kynureninase is to catalyze the cleavage of L-kynurenine into anthranilic acid and of L-3-hydroxykynurenine into 3-hydroxyanthranilic acid, exhibiting a preference for the L-3-hydroxy form. Kynureninase forms a homodimer, uses pyridoxal phosphate as a cofactor and is inhibited by o-methoxybenzoylalanine (OMBA) . Kynureninase is widely expressed, with highest levels found in lung, placenta and liver. Deficiency in kynureninase leads to hyperkynureninuria, a disorder characterized by the inability to break down tryptophan to nicotinic acid (vitamin B6) . Increased levels of kynureninase activity are observed in systemic and cerebral inflammatory conditions.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: KYNU polyclonal Antibody detects endogenous levels of KYNU protein.

Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Kynureninase; L-kynurenine hydrolase ; KYNU

Immunogen: Recombinant full length Human KYNU.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: