L-189 | 9674

L-189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L-189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

L-189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L-189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

9674 | L-189 DataSheet

Alternate Name/Synonyms: (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Appearance: White solid

Formulation: N/A

CAS Number: 64232-83-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₀N₄OS

Molecular Weight: 246.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A DNA ligase I, III and IV inhibitor

MDL Number: N/A

PubChem CID: 824710

SMILES: C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N

InChi: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)

InChi Key: SAKOXVNKDMWWLF-UHFFFAOYSA-N