L-67 | 9633

L-67 is a competitive human DNA ligase inhibitor, that inhibits DNA ligases I and III with IC₅₀ values of 10 μM and 10 μM. L-67 significantly increases the cytotoxicity of DNA damaging agents. L-67 also inhibits cell proliferation.

L-67 is a competitive human DNA ligase inhibitor, that inhibits DNA ligases I and III with IC₅₀ values of 10 μM and 10 μM. L-67 significantly increases the cytotoxicity of DNA damaging agents. L-67 also inhibits cell proliferation.

9633 | L-67 DataSheet

Alternate Name/Synonyms: E-2-((3,5-Dibromo-4-methylphenyl)amino)-N’-(2-hydroxy-5-nitrobenzylidene)acetohydrazide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 325970-71-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄Br₂N₄O₄

Molecular Weight: 486.11

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A competitive human DNA ligase inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C

InChi: InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+

InChi Key: KFEPVFJQVOMODD-IFRROFPPSA-N