L-838,417 | B1281

L-838, 417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α1, α2, α3 and α5 subunits (Kivalues are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

L-838, 417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α1, α2, α3 and α5 subunits (Kivalues are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

B1281 | L-838,417 DataSheet

Alternate Name/Synonyms: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

Appearance: White solid

Formulation: N/A

CAS Number: 286456-42-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉F₂N₇O

Molecular Weight: 399.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A subtype-selective GABAA receptor partial agonist

MDL Number: N/A

PubChem CID: 9908880

SMILES: CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F

InChi: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3

InChi Key: BQDUNOMMYOKHEP-UHFFFAOYSA-N