L-Buthionine-(S,R)-Sulfoximine | B2305

L-Buthionine-(S,R)-Sulfoximine is a potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells.

L-Buthionine-(S,R)-Sulfoximine is a potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells.

B2305 | L-Buthionine-(S,R)-Sulfoximine DataSheet

Alternate Name/Synonyms: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 83730-53-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₈H₁₈N₂O₃S

Molecular Weight: 222.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: PBS, pH 7.2 (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase

MDL Number: MFCD00067000

PubChem CID: 119565

SMILES: CCCCS(=N)(=O)CCC(C(=O)O)N

InChi: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1

InChi Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N