L-DON | B1955

L-DON is a glutamine antagonist produced naturally by Streptomyces; it inhibits several glutamine-dependent enzyme pathways as well as acts as an inhibitor of the mitochondrial enzyme, glutaminase (GLS), the primary producer of neuronal glutamate.

L-DON is a glutamine antagonist produced naturally by Streptomyces; it inhibits several glutamine-dependent enzyme pathways as well as acts as an inhibitor of the mitochondrial enzyme, glutaminase (GLS), the primary producer of neuronal glutamate.

B1955 | L-DON DataSheet

Alternate Name/Synonyms: H-Glu(diazomethylketone)-OH, 6-Diazo-5-oxo-L-2-aminohexanoic acid; 6-Diazo-5-oxo-L-norleucine

Appearance: Yellow solid

Formulation: N/A

CAS Number: 157-03-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₉N₃O₃

Molecular Weight: 171.16

Cell-Permeable?: Yes

Purity: ≥95% by TLC

Solubilities: PBS (pH 7.2, 10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A glutamine antagonist

MDL Number: MFCD00037218

PubChem CID: 5359375

SMILES: C(CC(=C[N+]#N)[O-])C(C(=O)O)N

InChi: InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H-,10,11,12)/b4-3-/t5-/m0/s1

InChi Key: MKZFABOMIIHLIT-XUELKZDXSA-N