L002 | B2859

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.

B2859 | L002 DataSheet

Alternate Name/Synonyms: [(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate; 4-(4-methoxyphenylsulfonyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone; (3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino 4-methoxybenzene-1-sulfonate; (3,5-dimethyl-4-oxocyclohexa-2,5-dienylidene)azamethyl 4-methoxybenzenesulfonate; 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; NSC764414; p300/CBP Inhibitor VI

Appearance: A crystalline solid

Formulation:

CAS Number: 321695-57-2

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₅H₁₅NO₅S

Molecular Weight: 321.35

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~1 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of p300 histone acetyltransferase

MDL Number:

PubChem CID: 2221149

SMILES: CC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C

InChi: InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3

InChi Key: VEWFTYOFWIXCIO-UHFFFAOYSA-N