LAG3 Antibody (Center) [APR05829G]

LAG3 Antibody (Center) [APR05829G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This LAG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human LAG3.

Cellular Localisation: [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 57449

Clone: Polyclonal

Gene Name: LAG3 (HGNC:6476)

Gene ID: 3902

Function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648) . Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity) . FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity) . Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity) . May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity) . Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8 (+) and CD4 (+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648) . Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity) . Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity) . Binds MHC class II (MHC-II) ; the precise role of MHC-II-binding is however unclear (PubMed:8647185) .

Summary: Tissue Location: Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Lymphocyte activation gene 3 protein, LAG-3, Protein FDC, CD223, LAG3, FDC