Lamin A/C (phospho-S22) polyclonal Antibody | BS74023

Lamin A/C (phospho-S22) polyclonal Antibody | BS74023 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Lamin A/C (phospho-S22) polyclonal Antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser22.

Molecular Weight: ~ 69, 78 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen: A phospho specific peptide corresponding to residues surrounding S22 of human LMNA

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Examples of Crosstalk Between Post-translational Modifications,