Lamotrigine | B1234

Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC₅₀ values of 10, 62, and 96 μM, respectively. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.

Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC₅₀ values of 10, 62, and 96 μM, respectively. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.

B1234 | Lamotrigine DataSheet

Alternate Name/Synonyms: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

Appearance: White solid

Formulation:

CAS Number: 84057-84-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₇Cl₂N₅

Molecular Weight: 256.09

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of voltage-gated sodium channels (Nav)

MDL Number: MFCD00865333

PubChem CID: 3878

SMILES: C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N

InChi: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChi Key: PYZRQGJRPPTADH-UHFFFAOYSA-N