LAMP1 Antibody (C-term) [APR07122G]

LAMP1 Antibody (C-term) [APR07122G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LAMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-417 amino acids from the C-terminal region of human LAMP1.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity) . Colocalizes with OSBPL1A at the late endosome (PubMed:16176980) . {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}

Molecular Weight: 44882

Clone: Polyclonal

Gene Name: LAMP1 (HGNC:6499)

Gene ID: 3916

Function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity) . Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921) . Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890) . In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195) . Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP1