Lanraplenib | B3307

Lanraplenib is a potent and selective second generation SYK inhibitor (IC50=9.5 nM). Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.

Lanraplenib is a potent and selective second generation SYK inhibitor (IC50=9.5 nM). Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.

B3307 | Lanraplenib DataSheet

Alternate Name/Synonyms: GS-9876 6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine

Appearance: Solid

Formulation:

CAS Number: 1800046-95-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅N₉O

Molecular Weight: 443.5

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~40 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly selective and orally active SYK inhibitor

MDL Number:

PubChem CID: 118161062

SMILES: C1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N

InChi: InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)

InChi Key: XCIGZBVOUQVIPI-UHFFFAOYSA-N