Lasmiditan hemisuccinate | B3032

Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical stimulation of the trigeminal ganglion in rodent models of migraine. It is approved for the acute treatment of migraine with or without aura in adults.

Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical stimulation of the trigeminal ganglion in rodent models of migraine. It is approved for the acute treatment of migraine with or without aura in adults.

B3032 | Lasmiditan hemisuccinate DataSheet

Alternate Name/Synonyms: Lasmiditan succinate; butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide; 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate; Butanedioic acid, compd. with 2,4,6-trifluoro-N-(6-((1-methyl-4-piperidinyl)carbonyl)-2-pyridinyl)benzamide (1:2); COL-144; LY573144

Appearance: Solid

Formulation:

CAS Number: 439239-92-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₄₂H₄₂F₆N₆O₈

Molecular Weight: 872.8

Cell-Permeable?: FALSE

Purity: ≥98%

Solubilities: ~9 mg/ml in ethanol, ~14 mg/ml in water, ~100 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly selective serotonin 5-HT(1F) receptor agonist

MDL Number: MFCD31728527

PubChem CID: 46927777

SMILES: CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.C(CC(=O)O)C(=O)O

InChi: InChI=1S/2C19H18F3N3O2.C4H6O4/c2*1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22;5-3(6)1-2-4(7)8/h2*2-4,9-11H,5-8H2,1H3,(H,23,24,27);1-2H2,(H,5,6)(H,7,8)

InChi Key: MSOIHUHNGPOCTH-UHFFFAOYSA-N