LDL Receptor polyclonal Antibody | BS90794

LDL Receptor polyclonal Antibody | BS90794 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF) -like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LDL Receptor polyclonal Antibody detects endogenous levels of LDL Receptor protein.

Molecular Weight: 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LDL receptor, FH, FHC, LDL R, LDL receptor, LDLCQ2, Ldlr, LDLR, Low Density Lipoprotein Receptor, Low density lipoprotein receptor class A domain containing protein 3, Low density lipoprotein receptor familial hypercholesterolemia, Low-density lipoprotein receptor,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: