LDLRAD1 polyclonal Antibody | BS61636

LDLRAD1 polyclonal Antibody | BS61636 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Low-density lipoprotein receptor class A domain-containing protein 1, belonging to the Low-density lipoprotein receptor class A domain-containing protein family.LDLRAD1 and LDLRAD2 function as recetor, LDLRAD3 may influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production,LDLRAD3 functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LDLRAD1 polyclonal Antibody detects endogenous levels of LDLRAD1 protein.

Molecular Weight: ~ 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Low-density lipoprotein receptor class A domain-containing protein 1; LDLRAD1

Immunogen: Synthetic peptide, corresponding Human LDLRAD1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk,Cell Cycle G2 M DNA Damage Signaling Pathway,