LDN-192960 hydrochloride | B3285

LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It displays selectivity for Haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM).

LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It displays selectivity for Haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM).

B3285 | LDN-192960 hydrochloride DataSheet

Alternate Name/Synonyms: 3-[(2,7-dimethoxy-9-acridinyl)thio]-1-propanamine, dihydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 2309172-48-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₀N₂O₂S • 2HCl

Molecular Weight: 401.4

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) inhibitor

MDL Number:

PubChem CID: 91885401

SMILES: COC1=CC2=C(SCCCN)C3=CC(OC)=CC=C3N=C2C=C1.Cl.Cl

InChi: InChI=1S/C18H20N2O2S.2ClH/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16;;/h4-7,10-11H,3,8-9,19H2,1-2H3;2*1H

InChi Key: FNHCUCJBABESJB-UHFFFAOYSA-N