LDN-212854 | B2641

LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC₅₀ values < 100 nM).

LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC₅₀ values < 100 nM).

B2641 | LDN-212854 DataSheet

Alternate Name/Synonyms: LDN212854; 5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

Appearance: Yellow solid

Formulation:

CAS Number: 1432597-26-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₂N₆

Molecular Weight: 406.48

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent bone morphogenetic protein type I (ALK) inhibitor

MDL Number:

PubChem CID: 60182388

SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3

InChi: InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2

InChi Key: BBDGBGOVJPEFBT-UHFFFAOYSA-N