LECT1 polyclonal Antibody | BS8321

LECT1 polyclonal Antibody | BS8321 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:100

Background: ChM-1 is a cartilage-specific matrix glycoprotein that stimulates the growth of chondrocytes. ChM-1 inhibits angiogenesis by disrupting the tube formation of endothelial cells and thus is responsible for the avascular nature of cartilage. ChM-1 is strongly expressed by the proliferating and hypertrophic zones in the epiphyseal plate of long bones. ChM-1 accumulates in the interterritorial matrix around the lacunae. During development, downregulation of ChM-1 permits angiogenesis and ultimately bone formation on the cartilage template. ChM-1 expression is downregulated in the presence of several growth factors including TGFβ2, FGF2 and PTHLH. ChM-1 expression may also play a role in the hypovascularity and chondroid formation of pleomorphic adenomas. The gene encoding human ChM-1 maps to chromosome 13q14-q21.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LECT1 polyclonal Antibody detects endogenous levels of LECT1 protein.

Molecular Weight: ~ 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Leukocyte cell-derived chemotaxin 1; Chondromodulin-I; ChM-I; LECT1; CHMI

Immunogen: Recombinant full length Human LECT1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: