Leelamine hydrochloride | 2717

Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine is also an inhibitor of pyruvate dehydrogenase kinase (PDK) (IC₅₀ = 9.5 µM). Recently, Leelamine has been shown to simultaneously inhibit PI3K, MAPK and STAT3 pathways.

Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine is also an inhibitor of pyruvate dehydrogenase kinase (PDK) (IC₅₀ = 9.5 µM). Recently, Leelamine has been shown to simultaneously inhibit PI3K, MAPK and STAT3 pathways.

2717 | Leelamine hydrochloride DataSheet

Alternate Name/Synonyms: 1R,​2,​3,​4,​4aS,​9,​10,​10aR-​octahydro-​1,​4a-​dimethyl-​7-​(1-​methylethyl)-​1-​phenanthrenemethanamine, hydrochloride; Dehydroabietylamine

Appearance: White solid

Formulation: N/A

CAS Number: 16496-99-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₃₁N.HCl

Molecular Weight: 321.93

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 30 mg/ml) or EtOH (~30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A pyruvate dehydrogenase kinase inhibitor

MDL Number: N/A

PubChem CID: 46780578

SMILES: CCCC1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C

InChi: InChI=1S/C20H31N/c1-4-6-15-7-9-17-16(13-15)8-10-18-19(2,14-21)11-5-12-20(17,18)3/h7,9,13,18H,4-6,8,10-12,14,21H2,1-3H3/t18?,19-,20+/m0/s1

InChi Key: GWCJWLXMNCMNTG-NRRUETGQSA-N