Description
Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine is also an inhibitor of pyruvate dehydrogenase kinase (PDK) (IC₅₀ = 9.5 µM). Recently, Leelamine has been shown to simultaneously inhibit PI3K, MAPK and STAT3 pathways.
Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine is also an inhibitor of pyruvate dehydrogenase kinase (PDK) (IC₅₀ = 9.5 µM). Recently, Leelamine has been shown to simultaneously inhibit PI3K, MAPK and STAT3 pathways.
2717 | Leelamine hydrochloride DataSheet
Alternate Name/Synonyms: 1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, hydrochloride; Dehydroabietylamine
Appearance: White solid
Formulation: N/A
CAS Number: 16496-99-4
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₃₁N.HCl
Molecular Weight: 321.93
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 30 mg/ml) or EtOH (~30 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A pyruvate dehydrogenase kinase inhibitor
MDL Number: N/A
PubChem CID: 46780578
SMILES: CCCC1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C
InChi: InChI=1S/C20H31N/c1-4-6-15-7-9-17-16(13-15)8-10-18-19(2,14-21)11-5-12-20(17,18)3/h7,9,13,18H,4-6,8,10-12,14,21H2,1-3H3/t18?,19-,20+/m0/s1
InChi Key: GWCJWLXMNCMNTG-NRRUETGQSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |