LBD
LEF1 Antibody (N-term) [APR03650G]
- SKU:
- LBD-APR03650G
- Availability:
- Usually ships in 5 working days
Description
LEF1 Antibody (N-term) [APR03650G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This LEF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human LEF1.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding.
Molecular Weight: 44201
Clone: Polyclonal
Gene Name: LEF1
Gene ID: 51176
Function: Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090) . Participates in the Wnt signaling pathway (By similarity) . Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity) . PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity) . TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540) . Regulates T-cell receptor alpha enhancer function (PubMed:19653274) . Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity) . May play a role in hair cell differentiation and follicle morphogenesis (By similarity) .
Summary: Tissue Location: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IF
Dilution: WB--1:2000
Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha, LEF1