Leflunomide | 1972

Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNF-dependent NF-κB activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.

Leflunomide is an immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNF-dependent NF-κB activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.

1972 | Leflunomide DataSheet

Alternate Name/Synonyms: 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide; HWA486,

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 75706-12-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₉F₃N₂O₂

Molecular Weight: 270.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM) or Ethanol (100 mM)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An immunosuppressant and a Tyrosine kinase inhibitor

MDL Number: MFCD00867593

PubChem CID: 3899

SMILES: CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

InChi: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13, 14)15/h2-6H,1H3,(H,17,18)

InChi Key: VHOGYURTWQBHIL-UHFFFAOYSA-N