VEGF-A Antibody| F41972-0.08ML/F41972-0.4ML

VEGF-A Antibody| F41972-0.08ML/F41972-0.4ML | Gentaur UK, US & Europe Distribution

Background: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the VEGF-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This VEGF-A antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 140-168 from the human protein was used as the immunogen for this VEGF-A antibody.

Storage: Aliquot the VEGF-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A