Leniolisib | B2435

Leniolisib is a potent and selective PI3Kδ inhibitor with an IC₀ of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular selectivity over PI3Kα. Inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells in vitro.

Leniolisib is a potent and selective PI3Kδ inhibitor with an IC₀ of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular selectivity over PI3Kα. Inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells in vitro.

B2435 | Leniolisib DataSheet

Alternate Name/Synonyms: 1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-

Appearance: Crystalline solid

Formulation:

CAS Number: 1354690-24-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₅F₃N₆O₂₅

Molecular Weight: 450.46

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective PI3Kδ inhibitor

MDL Number:

PubChem CID: 57495353

SMILES: CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CN=C(C(=C4)C(F)(F)F)OC

InChi: InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1

InChi Key: MWKYMZXCGYXLPL-ZDUSSCGKSA-N