LEPR Polyclonal Antibody | E-AB-53262

LEPR Polyclonal Antibody | E-AB-53262 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CD 295, CD295, CD295 antigen, Db, Fa, HuB219, LEP R, LEP-R, LEPR, LEPR, LEPRD, Leptin receptor, Leptin receptor fatty, Leptin receptor gene related protein, Leptin receptor precursor, Leptin receptor precursor, OB R gene related protein, OB receptor, OB-R, OB-RGRP, obl, Obr

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Concentration: 0.84 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human LEPR

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 133 kDa

Molecular Weight(Observed): Refer to figures