Description
Lexibulin is an orally available inhibitor of microtubule polymerization with an IC₅₀ of 3 µM. It blocks cell cycle at the G2-M phase, which leads to cell death. It is cytotoxic to various cell lines with IC₅₀ values ranging from 10-100 nM. It shows antitumor activity in prostate cancer and breast cancer in vivo models. It exhibits antivascular activity in vitro and in vivo.
Lexibulin is an orally available inhibitor of microtubule polymerization with an IC₅₀ of 3 µM. It blocks cell cycle at the G2-M phase, which leads to cell death. It is cytotoxic to various cell lines with IC₅₀ values ranging from 10-100 nM. It shows antitumor activity in prostate cancer and breast cancer in vivo models. It exhibits antivascular activity in vitro and in vivo.
Alternate Name/Synonyms: CYT997; 1-ethyl-3-[2-methoxy-4-[5-methyl-4-[[(1S)-1-pyridin-3-ylbutyl]amino]pyrimidin-2-yl]phenyl]urea
Appearance: White to off-white solid
Formulation:
CAS Number: 917111-44-5
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₂₄H₃₀N₆O₂
Molecular Weight: 434.5
Cell-Permeable?: True
Purity: ≥ 97%
Solubilities: ~20 mg/ml in DMSO or DMF, ~16 mg/ml in ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An orally available inhibitor of microtubule polymerization
MDL Number: MFCD18206787
PubChem CID: 11351021
SMILES: CCCC(C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC
InChi: InChI=1S/C24H30N6O2/c1-5-8-19(18-9-7-12-25-15-18)28-22-16(3)14-27-23(30-22)17-10-11-20(21(13-17)32-4)29-24(31)26-6-2/h7,9-15,19H,5-6,8H2,1-4H3,(H2,26,29,31)(H,27,28,30)/t19-/m0/s1
InChi Key: MTJHLONVHHPNSI-IBGZPJMESA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |
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