LGALS8 Antibody (C-term) [APR04270G]

LGALS8 Antibody (C-term) [APR04270G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LGALS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-298 amino acids from the C-terminal region of human LGALS8.

Cellular Localisation: Cytoplasmic vesicle. Cytoplasm, cytosol

Molecular Weight: 35808

Clone: Polyclonal

Gene Name: LGALS8 (HGNC:6569)

Gene ID: 3964

Function: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878) . Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878) . Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878) . Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324) . Also required to restrict infection of Picornaviridae viruses (PubMed:28077878) . Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902) .

Summary: Tissue Location: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8