LH-846 | 9423

LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.

LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.

9423 | LH-846 DataSheet

Alternate Name/Synonyms: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

Appearance: White solid

Formulation: N/A

CAS Number: 639052-78-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₃ClN₂OS

Molecular Weight: 316.81

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A casein kinase (CK) 1δ inhibitor

MDL Number: N/A

PubChem CID: 851474

SMILES: CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3

InChi: InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)

InChi Key: DYHAMRNAHTWYKY-UHFFFAOYSA-N