Description
LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.
LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.
Alternate Name/Synonyms: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Appearance: White solid
Formulation: N/A
CAS Number: 639052-78-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₃ClN₂OS
Molecular Weight: 316.81
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A casein kinase (CK) 1δ inhibitor
MDL Number: N/A
PubChem CID: 851474
SMILES: CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
InChi: InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
InChi Key: DYHAMRNAHTWYKY-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |