LIG3 Antibody (C-term) [APR31359G]

LIG3 Antibody (C-term) [APR31359G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LIG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 793-822 amino acids from the C-terminal region of human LIG3.

Cellular Localisation: [Isoform 1]: Mitochondrion Note=Contains an N-terminal mitochondrial transit peptide [Isoform 3]: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide.

Molecular Weight: 112907

Clone: Polyclonal

Gene Name: LIG3

Gene ID: 3980

Function: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627) .

Summary: Tissue Location: Testis, thymus, prostate and heart.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: DNA ligase 3, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3