BW
LIMK1/2 (P514) polyclonal Antibody | BS5526
- SKU:
- BW-BS5526
- Availability:
- Usually ships in 5 working days
Description
LIMK1/2 (P514) polyclonal Antibody | BS5526 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: LIMK1/2 (D402) pAb detects endogenous levels of LIMK1 and LIMK 2 protein.
Molecular Weight: ~ 72 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: LIM domain kinase 1; LIMK-1; LIMK1; LIMK; LIM domain kinase 2; LIMK 2; LIMK2
Immunogen: Synthetic peptide, corresponding to amino acids 500-550 of Human LIMK1.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A