LINGO-1 (LRRN6A) -S596 (C-term) Antibody [APR11272G]

LINGO-1 (LRRN6A) -S596 (C-term) Antibody [APR11272G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This LINGO-1 (LRRN6A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LINGO-1 (LRRN6A) .

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 69101

Clone: Polyclonal

Gene Name: Lingo1

Gene ID: 235402

Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity) . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

Summary: Tissue Location: Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000-1:2000

Synonyms: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a