LIPA polyclonal Antibody | BS8175

LIPA polyclonal Antibody | BS8175 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: The Lipase gene family is part of one of the largest genetic superfamilies in living organisms. Members of the AB hydrolase subfamily all contain an enzyme core with an α/β sheet, not barrel, of eight β-sheets connected by α-helices. The AB hydrolase subfamily plays a crucial role in the metabolism of lipids. Members of this family include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL), pancreatic lipase (PL), gastric lipase (GL), LCAT, and lysosomal acid lipase (LAL) . LAL is the important enzyme in the hydrolysis of triglycerides and cholesteryl esters in lysosomes. LAL has six potential N-glycosylation sites and one potential O-glycosylation site, and it is mediated by macrophage mannose receptors. Defects in the LAL gene have been linked to Wolman disease (WD) and CE storage disease (CESD), while overexpression of LAL leads to atherosclerosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LIPA polyclonal Antibody detects endogenous levels of LIPA protein.

Molecular Weight: ~ 40-45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Lysosomal acid lipase/cholesteryl ester hydrolase; Acid cholesteryl ester hydrolase; LAL; Cholesteryl esterase; Lipase A; Sterol esterase; LIPA

Immunogen: Recombinant full length Human LIPA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: