LIT-927 | B2432

LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.

LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.

B2432 | LIT-927 DataSheet

Alternate Name/Synonyms: 4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one, LIT927

Appearance: Crystalline solid

Formulation:

CAS Number: 2172879-52-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₃ClN₂O₃

Molecular Weight: 328.75

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective CXCL12 neutraligand

MDL Number:

PubChem CID: 137287575

SMILES: COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=C(C=C3)Cl)O

InChi: InChI=1S/C17H13ClN2O3/c1-23-16-8-11(4-7-15(16)21)14-9-13(19-17(22)20-14)10-2-5-12(18)6-3-10/h2-9,21H,1H3,(H,19,20,22)

InChi Key: BYYRNPIGDRRGLJ-UHFFFAOYSA-N