Description
LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.
LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.
Alternate Name/Synonyms: 4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one, LIT927
Appearance: Crystalline solid
Formulation:
CAS Number: 2172879-52-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₃ClN₂O₃
Molecular Weight: 328.75
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >10 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective CXCL12 neutraligand
MDL Number:
PubChem CID: 137287575
SMILES: COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=C(C=C3)Cl)O
InChi: InChI=1S/C17H13ClN2O3/c1-23-16-8-11(4-7-15(16)21)14-9-13(19-17(22)20-14)10-2-5-12(18)6-3-10/h2-9,21H,1H3,(H,19,20,22)
InChi Key: BYYRNPIGDRRGLJ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |