Description
A Stat3 phosphorylation inhibitor. LLL12 inhibits STAT3 phosphorylation (Tyr705) and STAT3 activities and down-regulates STAT3 downstream targets; inhibits proliferation, colony formation, and cell migration and induces apoptosis in various human breast and pancreatic cancer cells as well as in glioblastoma cells. LLL12 has minimal apoptotic effects on normal human cells.
LLL12 is a Stat3 phosphorylation inhibitor. LLL12 inhibits STAT3 phosphorylation (Tyr705) and STAT3 activities and down-regulates STAT3 downstream targets; inhibits proliferation, colony formation, and cell migration and induces apoptosis in various human breast and pancreatic cancer cells as well as in glioblastoma cells.
Alternate Name/Synonyms: 5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
Appearance: Lyophilized solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₉NO₅S
Molecular Weight: 303.29
Cell-Permeable?: Yes
Purity: ≥95% by ¹H NMR
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Stat3 phosphorylation inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: N/A
InChi: N/A
InChi Key: N/A
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |