LMAN1 Antibody | XW-7869

LMAN1 Antibody | XW-7869 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human

Homology: N/A

Immunogen: 270-470

Research Area: Homeostasis

Tested Application: WB

Application: ERGIC-53 protein antibody can be used for the detection of ERGIC-53 protein by Western Blot.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 57.5 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Immunoaffinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: LMAN1 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: ERGIC53, F5F8D, Protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein, MR60, gp58, FMFD1, MCFD1, ERGIC53, ERGIC-53, ERGIC53 protein, Lectin, mannose-binding 1, Gp58, Intracellular mannose-specific lectin MR60

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: FUNCTION: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

DISEASE: Defects in LMAN1 are a cause of factor V and factor VIII combined deficiency (F5F8D) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1) . F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins. Affected patients present with a moderate bleeding tendency and have factor V and factor VIII levels in the range of 5-30% of normal.