LMBR1L Antibody (C-term) [APR32740G]

LMBR1L Antibody (C-term) [APR32740G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LMBR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-489 amino acids from the C-terminal region of human LMBR1L.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 55209

Clone: Polyclonal

Gene Name: LMBR1L

Gene ID: 55716

Function: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity) . In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity) . LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity) . Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685) .

Summary: Tissue Location: Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Protein LMBR1L, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, Lipocalin-interacting membrane receptor, LMBR1L, KIAA1174, LIMR