LMTK3 Antibody (N-term) [APR17222G]

LMTK3 Antibody (N-term) [APR17222G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This LMTK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-187 amino acids from the N-terminal region of human LMTK3.

Cellular Localisation: Membrane {ECO:0000250|UniProtKB:Q5XJV6}; Single- pass membrane protein {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, axon {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5XJV6}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5XJV6}. Note=Punctate pattern in cell projections

Molecular Weight: 153661

Clone: Polyclonal

Gene Name: LMTK3

Gene ID: N/A

Function: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:1000-1 2000

Synonyms: Serine/threonine-protein kinase LMTK3, Lemur tyrosine kinase 3, LMTK3, KIAA1883, TYKLM3