Lonidamine | B1058

Lonidamine is a derivative of indazole-3-carboxylic acid that inhibits glycolysis by the inactivation of hexokinase, an enzyme that catalyzes glucose as the first step in glycolysis. Also blocks CFTR Cl- channels in vitro. Acts as an anticancer and antispermatogenic agent in vitro and in vivo.

Lonidamine is a derivative of indazole-3-carboxylic acid that inhibits glycolysis by the inactivation of hexokinase, an enzyme that catalyzes glucose as the first step in glycolysis. Also blocks CFTR Cl- channels in vitro. Acts as an anticancer and antispermatogenic agent in vitro and in vivo.

B1058 | Lonidamine DataSheet

Alternate Name/Synonyms: 1-[(2,4-Dichlorophenyl)methyl]-1H-i​ndazole-3-carboxylic acid

Appearance: White solid

Formulation: N/A

CAS Number: 50264-69-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₀Cl₂N₂O₂

Molecular Weight: 321.16

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A hexokinase and glycolysis inhibitor

MDL Number: MFCD00866285

PubChem CID: 39562

SMILES: C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O

InChi: InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)

InChi Key: WDRYRZXSPDWGEB-UHFFFAOYSA-N