Description
Lonidamine is a derivative of indazole-3-carboxylic acid that inhibits glycolysis by the inactivation of hexokinase, an enzyme that catalyzes glucose as the first step in glycolysis. Also blocks CFTR Cl- channels in vitro. Acts as an anticancer and antispermatogenic agent in vitro and in vivo.
Lonidamine is a derivative of indazole-3-carboxylic acid that inhibits glycolysis by the inactivation of hexokinase, an enzyme that catalyzes glucose as the first step in glycolysis. Also blocks CFTR Cl- channels in vitro. Acts as an anticancer and antispermatogenic agent in vitro and in vivo.
Alternate Name/Synonyms: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Appearance: White solid
Formulation: N/A
CAS Number: 50264-69-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₀Cl₂N₂O₂
Molecular Weight: 321.16
Cell-Permeable?: Yes
Purity: ≥95%
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A hexokinase and glycolysis inhibitor
MDL Number: MFCD00866285
PubChem CID: 39562
SMILES: C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
InChi: InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
InChi Key: WDRYRZXSPDWGEB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |