LONP1 polyclonal Antibody | BS71985

LONP1 polyclonal Antibody | BS71985 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC

Application Range: WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094) . Alternatively spliced transcript variants have been found for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LONP1 polyclonal Antibody detects endogenous levels of LONP1 protein.

Molecular Weight: 105kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CODASS; LON; LONP; LonHS; PIM1; PRSS15; hLON

Immunogen: Recombinant protein of human LONP1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Vesicle Trafficking presynaptic signaling,