Lopinavir | 10-029

Lopinavir | 10-029 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 628, 8

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: A-157378.0; ABT-378; Aluviran

Background: The antiviral agent Lopinavir is a potent inhibitor of HIV-1 protease (Ki=1.3pM for wild-type enzyme) and has been shown to block the replication of clinical isolates of HIV (EC50s=5-52nM) . Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir) . Lopinavir/ritonavir inhibits the HIV protease enzyme by forming an inhibitor-enzyme complex thereby preventing cleavage of the gag-pol polyproteins. Immature, non- infectious viral particles are subsequently produced. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24) . HIV-PIs block prelamin A processing by directly affecting the enzymatic activity of ZMPSTE24 and in this way they may contribute to lipodystrophy in individuals undergoing HIV-PI treatment. It also has been shown to inhibit meningioma cell proliferation, induce apoptosis on lymphoma cells and inhibit insulin signaling. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. A initial randomized trial study was not successful.

Disclaimer: This product is for research use only.

Purity: greater than or equal to 98% (1H-NMR)

Formula: C37H48N4O5

Source: N/A

Solubility: Soluble in DMSO, methanol or ethanol. Insoluble in water.

InChi Key: KJHKTHWMRKYKJE-SUGCFTRWSA-N

Smiles: O=C1NCCCN1[C@@H] (C (C) C) C (N[C@@H] (CC2=CC=CC=C2) C[C@H] (O) [C@H] (CC3=CC=CC=C3) NC (COC4=C (C) C=CC=C4C) =O) =O

RTECS: N/A

Identity: N/A

Merck Index: N/A