Losmapimod | B2728

Losmapimod is a potent and selective p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively. Displays no significant activity for p38γ, p38δ (<25% inhibition at 10 uM), and COX-2; significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation in rat model of cardiovascular disease.

Losmapimod is a potent and selective p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively. Displays no significant activity for p38γ, p38δ (<25% inhibition at 10 uM), and COX-2; significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation in rat model of cardiovascular disease.

B2728 | Losmapimod DataSheet

Alternate Name/Synonyms: ,GW-856553,6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide

Appearance: Off-white to pale yellow solid

Formulation:

CAS Number: 585543-15-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₆FN₃O₂

Molecular Weight: 383.46

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective p38 MAP kinase inhibitor

MDL Number:

PubChem CID: 11552706

SMILES: CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C

InChi: InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)

InChi Key: KKYABQBFGDZVNQ-UHFFFAOYSA-N