LPAM-1 Antibody [DATK32] | 99-012

LPAM-1 Antibody [DATK32] | 99-012 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: AKR/Cum mouse T lymphoma cell line TK-1

Research Area: Immunology, Signal Transduction, Stem Cell

Tested Application: Flow

Application: LPAM-1 Antibody [DATK32] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.

Specificiy: LPAM-1

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [DATK32]

Isotype: IgG2a

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in PBS

Concentration: 0.5 mg/mL

Storage Condition: Store vial at -20˚C

Alternate Name: Integrin alpha4beta7, lymphocyte Peyer's patch adhesion molecule

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The lymphocyte Peyer���s patch adhesion molecule (LPAM-1) , also known as integrin alpha4beta7, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes but is also present on NK cells and eosinophils. The alpha4beta7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer���s patches and intestinal lamina propria. The monoclonal antibody DATK32 recognizes a conformational epitope on the heterodimer.