LRP5L Polyclonal Antibody | BS65694

LRP5L Polyclonal Antibody | BS65694 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Chicken,Sheep,

Application: WB,

Application Range: WB=1:500-2000

Background: Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF) -like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG) . LRP5L is a related protein that exists as two isoforms produced by alternative splicing.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LRP5L Polyclonal Antibody detects endogenous levels of LRP5L protein.

Molecular Weight: 28 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like; LRP5L; GP330; LRP5L_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human LRP5L

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: