LRSAM1 polyclonal Antibody | BS71366

LRSAM1 polyclonal Antibody | BS71366 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: LRSAM1 (leucine-rich repeat and sterile α motif-containing protein 1), also known as Tsg101-associated ligase, is a 723 amino acid E3 ubiquitin-protein ligase that mediates the monoubiquination of tsg 101, a regulator of vesicular trafficking. This leads to inactivation of the sorting of endocytic and exocytic cargos, such as EGF receptors and HIV-1 viral proteins. Mutations within the LRSAM1 gene have been identified in patients with Charcot-Marie-Tooth disease. There are three isoforms of LRSAM1 that are produced as a result of alternative splicing events.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LRSAM1 polyclonal Antibody detects endogenous levels of LRSAM1 protein.

Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TAL; UNQ6496/PRO21356; E3 ubiquitin-protein ligase LRSAM1

Immunogen: Recombinant protein of human LRSAM1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: