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LSD1, Human Recombinant | P1659
- SKU:
- 26-P1659-GEN
- Availability:
- Usually shipped in 5 working days
Description
The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.
P1659 | LSD1, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Human Recombinant LSD,LSD, Human Recombinant,Human Recombinant LSD1,Lysine-specific histone demethylase, 1KDM1, BHC110, AOF2, KIAA0601, KDM1A, lysine (K)-specific demethylase 1A
Alternates names: Human Recombinant LSD,LSD, Human Recombinant,Human Recombinant LSD1,Lysine-specific histone demethylase, 1KDM1, BHC110, AOF2, KIAA0601, KDM1A, lysine (K)-specific demethylase 1A
Taglines: Active human recombinant Lysine (K)-specific demethylase 1 protein
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source: Human
Accession #: BAA25527
Recombinant: TRUE
Source: Sf9 insect cells
Purity by SDS-PAGE: ≥ 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): ≥ 10 mU/mg
Biological activity:
Results:
Binding Capacity:
Unit Definition: One unit of LSD1 is the amount of enzyme that demethylates the Histone H3 Dimethyl Lysine4 Peptide substrate while generating 1 umol H2O2 per minute at pH 8.5 and 37 °C.
Molecular Weight: 93.9 kDa (His tag at the N-terminus)
Concentration: Lot specific
Appearance: Liquid protein
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
Additional Information
Storage Temperature: |
-80°C |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |