LTBP1 Antibody (C-term) [AMM08593G]

LTBP1 Antibody (C-term) [AMM08593G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This LTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1493-1525 amino acids from the C-terminal region of human LTBP1.

Cellular Localisation: Secreted. Secreted, extracellular space, extracellular matrix

Molecular Weight: 186796

Clone: Polyclonal

Gene Name: LTBP1 (HGNC:6714)

Gene ID: 4052

Function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931) . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403) . Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742) .

Summary: Tissue Location: Expressed in the aorta (at protein level) (PubMed:17293099) . Isoform Long: Expressed in fibroblasts (PubMed:17293099) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1, LTBP1