LTK Antibody (N-term) [APR08288G]

LTK Antibody (N-term) [APR08288G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-72 amino acids from the N-terminal region of human LTK.

Cellular Localisation: Membrane; Single-pass type I membrane protein.

Molecular Weight: 91681

Clone: Polyclonal

Gene Name: LTK

Gene ID: 4058

Function: Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

Summary: Tissue Location: Expressed in non-hematopoietic cell lines and T- and B-cell lines.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, LTK, TYK1